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Prevnar 20® helps protect against 20 serotypes responsible for the majority of IPD in children <5 years of age1-4

Prevnar 20 helps protect against the 20 Streptococcus pneumoniae serotypes in the vaccine.1  There are no studies that compare the efficacy of Prevnar 20 to a 15-valent PCV.

Prevnar 20 helps protect against the 20 Streptococcus pneumoniae serotypes in the vaccine.1 

There are no studies that compare the efficacy of Prevnar 20 to a 15-valent PCV.

Percentage of IPD cases potentially covered by vaccine serotypes4* 

CDC surveillance data in children <5 years of age in the US, 2022

 Prevnar 20 is built on the efficacy and effectiveness of Prevnar† vaccines1,2
Understand the impact of Prevnar†
CDC=Centers for Disease Control and Prevention; IPD=invasive pneumococcal disease; OM=otitis media; PCV=pneumococcal conjugate vaccine; PCV7=7-valent pneumococcal conjugate vaccine.
*13 serotypes provide coverage for serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F. 15 serotypes provide coverage for all serotypes covered by 13 serotypes and the additional serotypes 22F and 33F. 20 serotypes provide coverage for all serotypes covered by 15 serotypes and the additional serotypes 8, 10A, 11A, 12F, and 15B.1-4​​
†Prevnar includes Prevnar® (Pneumococcal 7-valent Conjugate Vaccine [Diphtheria CRM197 Protein]), Prevnar 13® (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]), and Prevnar 20. In the US, Prevnar (PCV7) was available from 2000 to 2010, and Prevnar 13 was available from 2010 to 2024. Prevnar 20 has been available since 2023.1,2References:Prevnar 20® (Pneumococcal 20-valent Conjugate Vaccine) Prescribing Information. Wyeth Pharmaceuticals LLC, 2023.Prevnar 13® (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]) Prescribing Information. Wyeth Pharmaceuticals LLC, 2019.Vaxneuvance™ (Pneumococcal 15-valent Conjugate Vaccine) Prescribing Information. Merck Sharp & Dohme Corp, 2023.Centers for Disease Control and Prevention. ABCs Bact Facts Interactive data dashboard. Streptococcus pneumoniae. May 22, 2024. Accessed February 19, 2025. https://www.cdc.gov/abcs/bact-facts/data-dashboard.htmlSerotype Coverage

Consider the burden of IPD and OM in babies

 Explore disease burden LoadingCDC=Centers for Disease Control and Prevention; IPD=invasive pneumococcal disease; OM=otitis media; PCV=pneumococcal conjugate vaccine; PCV7=7-valent pneumococcal conjugate vaccine.
*13 serotypes provide coverage for serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F. 15 serotypes provide coverage for all serotypes covered by 13 serotypes and the additional serotypes 22F and 33F. 20 serotypes provide coverage for all serotypes covered by 15 serotypes and the additional serotypes 8, 10A, 11A, 12F, and 15B.1-4​​
†Prevnar includes Prevnar® (Pneumococcal 7-valent Conjugate Vaccine [Diphtheria CRM197 Protein]), Prevnar 13® (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]), and Prevnar 20. In the US, Prevnar (PCV7) was available from 2000 to 2010, and Prevnar 13 was available from 2010 to 2024. Prevnar 20 has been available since 2023.1,2References:Prevnar 20® (Pneumococcal 20-valent Conjugate Vaccine) Prescribing Information. Wyeth Pharmaceuticals LLC, 2023.Prevnar 13® (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]) Prescribing Information. Wyeth Pharmaceuticals LLC, 2019.Vaxneuvance™ (Pneumococcal 15-valent Conjugate Vaccine) Prescribing Information. Merck Sharp & Dohme Corp, 2023.Centers for Disease Control and Prevention. ABCs Bact Facts Interactive data dashboard. Streptococcus pneumoniae. May 22, 2024. Accessed February 19, 2025. https://www.cdc.gov/abcs/bact-facts/data-dashboard.html
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INDICATIONS 
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5 years of age
IMPORTANT SAFETY INFORMATION
  • Do not administer Prevnar 20® to individuals with a severe allergic reaction (eg, anaphylaxis) to any component of Prevnar 20® or to diphtheria toxoid
  • Safety and immunogenicity data on Prevnar 20® are not available for individuals in immunocompromised groups, and vaccination should be considered on an individual basis. Based on experience with pneumococcal vaccines, individuals with altered immunocompetence may have reduced immune responses to Prevnar 20®
  • Apnea following intramuscular vaccination has been observed in some infants born prematurely. Vaccination of premature infants should be based on the infant’s medical status and the potential benefits and risks
  • In individuals 2, 4, 6, and 12 through 15 months of age vaccinated with a 4-dose schedule, the most commonly reported solicited adverse reactions (>10%) were irritability, pain at the injection site, drowsiness, decreased appetite, injection site redness, injection site swelling, and fever
  • In individuals 15 months through 17 years of age vaccinated with a single dose, the most commonly reported solicited adverse reactions (>10%) were irritability, pain at the injection site, drowsiness, fatigue and muscle pain, decreased appetite, injection site swelling and redness, headache, and fever
Patients should always ask their healthcare providers for medical advice about adverse events. You are encouraged to report negative side effects of vaccines to the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). ​​Visit http://www.vaers.hhs.gov or call 1-800-822-7967.

Please click for Prevnar 20® Full Prescribing Information.INDICATIONSIndications
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5 years of age