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Online ordering allows you to submit an order for Prevnar 20® that will ship in 2 to 3 business days

Online ordering allows you to submit an order for Prevnar 20® that will ship in 2 to 3 business days

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Storage, handling, and administration

Storage, handling, and administrationImportant Packaging Information
  • Upon FDA approval of Prevnar 20® for pediatric use, Pfizer will be removing the statement “FOR USE IN INDIVIDUALS 18 YEARS OF AGE AND OLDER” from newly manufactured boxes
  • In the interim, product in its original packaging can be used in appropriate infants and children
  • Store pre-filled syringes in the refrigerator (2 °C to 8 °C). Do not freeze1
  • To minimize resuspension time, syringes should be stored horizontally, as directed on packaging1
  • Once removed from the refrigerator, Prevnar 20 should be used immediately1*
References*Stability data indicate that the vaccine is stable for 96 hours when stored at temperatures from 8 °C to 25 °C, or 72 hours when stored at temperatures from 0 °C to 2 °C. At the end of these time periods, Prevnar 20 should be used or discarded. These data are intended to guide healthcare professionals in case of temporary temperature excursion only.1Prevnar 20 is prepared and administered the same as Prevnar 13® (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein])1,2

Do not mix Prevnar 20 with other vaccines/products in the same syringe.

Step 1: Resuspend drug product

  • Hold the pre-filled syringe horizontally between the thumb and the forefinger and shake vigorously until the vaccine is a homogeneous white suspension
  • Do not use the vaccine if it cannot be resuspended

Step 2: Visual inspection

  • Visually inspect the vaccine for large particulate matter and discoloration prior to administration
  • Do not use if large particulate matter or discoloration is found. If the vaccine is not a homogeneous suspension, repeat Steps 1 and 2

Step 3: Remove syringe cap

  • Remove the syringe cap by slowly turning the cap counterclockwise while holding the Luer lock adapter
  • Avoid pressing the syringe plunger rod while removing the syringe cap

Step 4: Attach a sterile needle

  • Hold the Luer lock adapter and attach a needle appropriate for intramuscular administration to the pre-filled syringe by turning clockwise

Step 1: Resuspend drug product

  • Hold the pre-filled syringe horizontally between the thumb and the forefinger and shake vigorously until the vaccine is a homogeneous white suspension
​​​​​​​
  • Do not use the vaccine if it cannot be resuspended
Administration1
  • For intramuscular injection only
  • Each 0.5-mL dose is to be injected intramuscularly using a sterile needle attached to the supplied pre-filled syringe
    • The preferred sites for injection are the anterolateral aspect of the thigh in infants and the deltoid muscle of the upper arm in children and adults3
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LoadingReferences:Prevnar 20® (Pneumococcal 20-valent Conjugate Vaccine) Prescribing Information. Wyeth Pharmaceuticals LLC, 2023.Prevnar 13® (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]) Prescribing Information. Wyeth Pharmaceuticals LLC, 2019.Wolicki J, Miller E. Vaccine administration. In: Hall E, Wodi AP, Hamborsky J, Morelli V, Schillie S, eds. Epidemiology and Prevention of Vaccine-Preventable Diseases. Centers for Disease Control and Prevention. 14th ed. Public Health Foundation; 2021:69-96.
Manufactured by Wyeth Pharmaceuticals LLC.
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INDICATIONS 
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5 years of age
IMPORTANT SAFETY INFORMATION
  • Do not administer Prevnar 20® to individuals with a severe allergic reaction (eg, anaphylaxis) to any component of Prevnar 20® or to diphtheria toxoid
  • Safety and immunogenicity data on Prevnar 20® are not available for individuals in immunocompromised groups, and vaccination should be considered on an individual basis. Based on experience with pneumococcal vaccines, individuals with altered immunocompetence may have reduced immune responses to Prevnar 20®
  • Apnea following intramuscular vaccination has been observed in some infants born prematurely. Vaccination of premature infants should be based on the infant’s medical status and the potential benefits and risks
  • In individuals 2, 4, 6, and 12 through 15 months of age vaccinated with a 4-dose schedule, the most commonly reported solicited adverse reactions (>10%) were irritability, pain at the injection site, drowsiness, decreased appetite, injection site redness, injection site swelling, and fever
  • In individuals 15 months through 17 years of age vaccinated with a single dose, the most commonly reported solicited adverse reactions (>10%) were irritability, pain at the injection site, drowsiness, fatigue and muscle pain, decreased appetite, injection site swelling and redness, headache, and fever
Patients should always ask their healthcare providers for medical advice about adverse events. You are encouraged to report negative side effects of vaccines to the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). ​​Visit http://www.vaers.hhs.gov or call 1-800-822-7967.

Please click for Prevnar 20® Full Prescribing Information.INDICATIONSIndications
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5 years of age