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Prevnar 20®, the only pneumococcal vaccine option you need for babies, is recommended as a 4-dose series for new PCV starts1*†‡§Complete all 4 doses to optimize the Prevnar 20 immune response2
  • Midseries transition: Prevnar 20 is a recommended option for transition from PCV15 for children aged 2 to 23 months1
  • Completion of missed doses: Prevnar 20 is recommended for completion of missed PCV doses for children aged 24 to 59 months1
Prevnar 20 is the only pneumococcal vaccine option you need for children with certain underlying medical conditions that increase the risk of pneumococcal disease1* Choose vaccination status:

Fully vaccinated with
another PCV 

Unvaccinated

Incomplete

Tab Number 4

Tab Number 5

Aged 2 to 18 years with risk conditions1¶

Additional dose recommended:1 dose of Prevnar 20, given at least 8 weeks after last PCV dose1

No additional doses needed if Prevnar 20 was part of the 4-dose schedule.1

Aged 6 to 18 years with risk conditions1¶#

Additional dose recommended:1 dose of Prevnar 20

#No previous PCV13, PCV15, or PCV20 vaccination.1

Aged 24 to 71 months with risk conditions1¶

Additional doses recommended:Any incomplete schedule and <3 PCV doses by 24 months of age=2 doses of Prevnar 2013 PCV doses all at <12 months of age=1 dose of Prevnar 201

Given at least 8 weeks after last PCV dose.1

Children who have received a complete pneumococcal vaccine series that included Prevnar 20 do not need any additional doses.1 ACIP-recommended dosing Get the details about the dosing schedule Download the dosing flashcard LoadingCertain underlying medical conditions increase the risk of invasive pneumococcal disease (IPD)5¶

More than 1.2 million children who have asthma could have up to a 2.1x greater risk of IPD than healthy children5‖

Children aged 5 to 17 years with diabetes have up to 5.4x greater risk of IPD than healthy children5

More than 135,000 children who have chronic heart disease could have 2.4x to 9.9x greater risk of IPD than healthy children5

Some studies show that people with sickle cell disease have up to 40x greater risk of IPD than healthy children and young adults6

 Complete all 4 doses to optimize the Prevnar 20 immune response2
See post dose 4 Prevnar 20 antibody levels
LoadingDosing & Recommendations Stock Prevnar 20 for your patients

To stock Prevnar 20, call 1-800-666-7248 or click below to order on Pfizer Prime.

 Order today Importance of all 4 doses

See the CDC recommended pediatric pneumococcal dosing schedule for healthy babies and those with certain underlying medical conditions.

 Download to learn moreAAP=American Academy of Pediatrics; ACIP=Advisory Committee on Immunization Practices; CDC=Centers for Disease Control and Prevention; FAQ=frequently asked question; PCV=pneumococcal conjugate vaccine; PCV13=13-valent pneumococcal conjugate vaccine; PCV15=15-valent pneumococcal conjugate vaccine; PCV20=20-valent pneumococcal conjugate vaccine; PPSV23=23-valent pneumococcal polysaccharide vaccine.
*Children who have received Prevnar 20 and who have certain underlying medical conditions do not require a dose of PPSV23.1
†The first dose may be given as early as 6 weeks of age.2
‡The recommended dosing interval for the first, second, and third doses is 4 to 8 weeks.2
§The fourth dose should be administered at approximately 12 to 15 months of age and at least 2 months after the third dose.2
Risk conditions include cerebrospinal fluid leak, chronic heart disease, chronic kidney disease, chronic liver disease, chronic lung disease (including moderate persistent or severe persistent asthma), cochlear implant, diabetes mellitus, and immunocompromising conditions.1
‖The Centers for Disease Control and Prevention recommends Prevnar 20 in patients with underlying medical conditions, including moderate to severe asthma.1
**Children qualify for the VFC program if they are younger than 19 years of age, and either uninsured, underinsured, Medicaid eligible, or American Indian or Alaska Native.9References:Farrar JL, Gierke R, Andrejko KL, et al. Use of 20-valent pneumococcal conjugate vaccine among U.S. children: updated recommendations of the Advisory Committee on Immunization Practices — United States, 2023. MMWR Morb Mortal Wkly Rep. 2023;72(39):1072.Prevnar 20® (Pneumococcal 20-valent Conjugate Vaccine) Prescribing Information. Wyeth Pharmaceuticals LLC, 2023.Centers for Disease Control and Prevention. Recommended child and adolescent immunization schedule for ages 18 years or younger. Updated October 7, 2025. Accessed October 29, 2025. https://www.cdc.gov/vaccines/hcp/imz-schedules/downloads/child/0-18yrs-child-combined-schedule.pdf American Academy of Pediatrics. Recommended child and adolescent immunization schedule for ages 18 years or younger. Updated February 5, 2026. Accessed February 5, 2026. https://publications.aap.org/redbook/resources/15585/AAP-Immunization-SchedulePelton SI, Weycker D, Farkouh RA, Strutton DR, Shea KM, Edelsberg J. Risk of pneumococcal disease in children with chronic medical conditions in the era of pneumococcal conjugate vaccine. Clin Infect Dis. 2014;59(5):615-623. Yildirim I, Shea KM, Little BA, Silverio AL, Pelton SI; Members of the Massachusetts Department of Public Health. Vaccination, underlying comorbidities, and risk of invasive pneumococcal disease. Pediatrics. 2015;135(3):495-503.Centers for Disease Control and Prevention. Current CDC vaccine price list. January 6, 2026. Accessed January 12, 2026. https://www.cdc.gov/vaccines-for-children/php/awardees/current-cdc-vaccine-price-list.html Centers for Disease Control and Prevention. About the Vaccines for Children (VFC) Program. September 30, 2025. Accessed January 12, 2026. https://www.cdc.gov/vaccines-for-children/about/index.html Centers for Disease Control and Prevention. Vaccines for Children (VFC) Program eligibility. September 30, 2025. Accessed January 15, 2026. https://www.cdc.gov/vaccines-for-children/hcp/program-eligibility/index.html
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INDICATIONS 
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5 years of age
IMPORTANT SAFETY INFORMATION
  • Do not administer Prevnar 20® to individuals with a severe allergic reaction (eg, anaphylaxis) to any component of Prevnar 20® or to diphtheria toxoid
  • Safety and immunogenicity data on Prevnar 20® are not available for individuals in immunocompromised groups, and vaccination should be considered on an individual basis. Based on experience with pneumococcal vaccines, individuals with altered immunocompetence may have reduced immune responses to Prevnar 20®
  • Apnea following intramuscular vaccination has been observed in some infants born prematurely. Vaccination of premature infants should be based on the infant’s medical status and the potential benefits and risks
  • In individuals 2, 4, 6, and 12 through 15 months of age vaccinated with a 4-dose schedule, the most commonly reported solicited adverse reactions (>10%) were irritability, pain at the injection site, drowsiness, decreased appetite, injection site redness, injection site swelling, and fever
  • In individuals 15 months through 17 years of age vaccinated with a single dose, the most commonly reported solicited adverse reactions (>10%) were irritability, pain at the injection site, drowsiness, fatigue and muscle pain, decreased appetite, injection site swelling and redness, headache, and fever
Patients should always ask their healthcare providers for medical advice about adverse events. You are encouraged to report negative side effects of vaccines to the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). ​​Visit http://www.vaers.hhs.gov or call 1-800-822-7967.

Please click for Prevnar 20 Full Prescribing Information.INDICATIONSIndications
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5 years of age