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Prescribing InformationPatient InformationIndications Patient Site
Prevnar 20® achieved a 1.5- to 6.5-fold increase in antibody levels after dose 4 in babies in the pivotal study1*Help protect babies against IPD—deliver all 4 doses of Prevnar 20 on time1

Babies who received on-time PCV doses were up to 6x more likely to complete the series than those who received doses late.3†‡§

 IPD can be a serious condition for babies4

Learn about the risks of IPD caused by Streptococcus pneumoniae

Understand the disease burden
LoadingDosing & Recommendations Importance of all 4 doses 

See the CDC recommended pediatric pneumococcal dosing schedule for healthy babies and those with certain underlying medical conditions.

 Download to learn more LoadingGMC=geometric mean concentration; IgG=immunoglobulin G; PCV=pneumococcal conjugate vaccine.
*Pneumococcal antipolysaccharide IgG GMCs were calculated from blood samples taken from 831-833 infants and 753-755 toddlers who received a 4-dose series of Prevnar 20.1
†Babies who receive their first dose at ≥7 months of age are not indicated for the fourth dose.3
‡As observed in clinical practice with Prevnar 13® (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]). A dose was considered late if received after 119 days of age for dose 1, after 179 days of age for dose 2, and after 239 days of age for dose 3.3
§Based on an Optum Q1 2020 post hoc analysis of 2019 calendar year electronic healthcare records of babies aged 24 months who received the Prevnar 13 third dose in 2019, derived from healthcare provider organizations covering 105 million adult and pediatric patients in the US.3References:Prevnar 20® (Pneumococcal 20-valent Conjugate Vaccine) Prescribing Information. Wyeth Pharmaceuticals LLC, 2023.Centers for Disease Control and Prevention. Active Bacterial Core Surveillance (ABCs) report: Emerging Infections Program Network. Streptococcus pneumoniae, 2023. Updated March 20, 2025. Accessed May 20, 2025. 
https://www.cdc.gov/abcs/downloads/SPN_Surveillance_Report_2023.pdfData on file. Optum data 2022. Pfizer Inc.Gierke R, Wodi AP, Kobayashi M. Pneumococcal disease. In: Hall E, Wodi AP, Hamborsky J, Morelli V, Schillie S, eds. Epidemiology and Prevention of Vaccine-Preventable Diseases. Centers for Disease Control and Prevention. 14th ed. Public Health Foundation; 2021:255-274.
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INDICATIONS 
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5 years of age
IMPORTANT SAFETY INFORMATION
  • Do not administer Prevnar 20® to individuals with a severe allergic reaction (eg, anaphylaxis) to any component of Prevnar 20® or to diphtheria toxoid
  • Safety and immunogenicity data on Prevnar 20® are not available for individuals in immunocompromised groups, and vaccination should be considered on an individual basis. Based on experience with pneumococcal vaccines, individuals with altered immunocompetence may have reduced immune responses to Prevnar 20®
  • Apnea following intramuscular vaccination has been observed in some infants born prematurely. Vaccination of premature infants should be based on the infant’s medical status and the potential benefits and risks
  • In individuals 2, 4, 6, and 12 through 15 months of age vaccinated with a 4-dose schedule, the most commonly reported solicited adverse reactions (>10%) were irritability, pain at the injection site, drowsiness, decreased appetite, injection site redness, injection site swelling, and fever
  • In individuals 15 months through 17 years of age vaccinated with a single dose, the most commonly reported solicited adverse reactions (>10%) were irritability, pain at the injection site, drowsiness, fatigue and muscle pain, decreased appetite, injection site swelling and redness, headache, and fever
Patients should always ask their healthcare providers for medical advice about adverse events. You are encouraged to report negative side effects of vaccines to the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). ​​Visit http://www.vaers.hhs.gov or call 1-800-822-7967.

Please click for Prevnar 20 Full Prescribing Information.INDICATIONSIndications
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
  • Prevnar 20® is a vaccine indicated for active immunization for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F in individuals 6 weeks through 5 years of age